Drug Information

Drug General Information
Drug ID
D0R3EL
Former ID
DCL000372
Drug Name
GSK184072
Drug Type
Small molecular drug
Indication Colon cancer; Hematologic cancers; Type 2 diabetes [ICD9: 140-229, 250, 250.00, 250.02; ICD10:E08-E13, E11] Discontinued in Phase 2 [548320]
Company
GSK
Formula
C12H18N2O3
Canonical SMILES
CC(C)CC1=NC(=CC(C)C)C(=O)N(C1=O)O
InChI
1S/C12H18N2O3/c1-7(2)5-9-11(15)14(17)12(16)10(13-9)6-8(3)4/h5,7-8,17H,6H2,1-4H3/b9-5-
InChIKey
SIXHCCPAJIVTOY-UITAMQMPSA-N
PubChem Compound ID
6443207
PubChem Substance ID
811641, 11969039, 14847386, 43035735, 51449023, 57369372, 103179857, 114567661, 134339021, 134340028, 135165866
Target and Pathway
Target(s) NAD-dependent deacetylase sirtuin-1 Target Info Activator [550963]
KEGG Pathway FoxO signaling pathway
AMPK signaling pathway
Glucagon signaling pathway
Amphetamine addiction
MicroRNAs in cancer
PANTHER Pathway p53 pathway
Pathway Interaction Database p73 transcription factor network
Signaling events mediated by HDAC Class III
E2F transcription factor network
HIF-2-alpha transcription factor network
Signaling events mediated by HDAC Class I
FoxO family signaling
Regulation of Androgen receptor activity
Regulation of retinoblastoma protein
Reactome RORA activates gene expression
Regulation of HSF1-mediated heat shock response
Circadian Clock
WikiPathways Integrated Pancreatic Cancer Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Androgen receptor signaling pathway
References
Ref 548320Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024569)
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.