Drug Information

Drug General Information
Drug ID
D0Q6AD
Former ID
DNC010814
Drug Name
4'-(5-Chloro-2-thienyl)biphenyl-3-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530868]
Formula
C16H11ClOS
Canonical SMILES
C1=CC(=CC(=C1)O)C2=CC=C(C=C2)C3=CC=C(S3)Cl
InChI
1S/C16H11ClOS/c17-16-9-8-15(19-16)12-6-4-11(5-7-12)13-2-1-3-14(18)10-13/h1-10,18H
InChIKey
ABAQWDXYFZGNGR-UHFFFAOYSA-N
PubChem Compound ID
46887551
Target and Pathway
Target(s) Estradiol 17 beta-dehydrogenase 1 Target Info Inhibitor [530868]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome The canonical retinoid cycle in rods (twilight vision)
WikiPathways Steroid Biosynthesis
Metabolism of steroid hormones and vitamin D
Prostate Cancer
References
Ref 530868Bioorg Med Chem. 2010 May 15;18(10):3494-505. Epub 2010 Mar 29.Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.
Ref 530868Bioorg Med Chem. 2010 May 15;18(10):3494-505. Epub 2010 Mar 29.Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.

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