Drug Information

Drug General Information
Drug ID
D0Q4UA
Former ID
DIB021253
Drug Name
Z-Arg-Leu-Val-Agly-Ile-Val-OMe
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541662]
Formula
C38H64N10O9
InChI
InChI=1S/C38H64N10O9/c1-10-24(8)30(33(51)45-29(23(6)7)35(53)56-9)46-37(54)48-47-34(52)28(22(4)5)44-32(50)27(19-21(2)3)42-31(49)26(17-14-18-41-36(39)40)43-38(55)57-20-25-15-12-11-13-16-25/h11-13,15-16,21-24,26-30H,10,14,17-20H2,1-9H3,(H,42,49)(H,43,55)(H,44,50)(H,45,51)(H,47,52)(H4,39,40,41)(H2,46,48,54)/t24-,26-,27-,28-,29-,30-/m0/s1
InChIKey
ZLXFGUGFOLETFJ-POPCVQDUSA-N
PubChem Compound ID
10033311
PubChem Substance ID
15014885, 44150378, 75172715, 160699878, 163358610, 178103148
Target and Pathway
Target(s) Cathepsin B Target Info Inhibitor [526417]
KEGG Pathway Lysosome
Antigen processing and presentation
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
Reactome Collagen degradation
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
References
Ref 541662(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6534).
Ref 526417J Med Chem. 2002 Sep 12;45(19):4202-11.Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases.

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