Drug Information

Drug General Information
Drug ID
D0Q0JI
Former ID
DIB002573
Drug Name
ASP-4058
Indication Multiple scierosis [ICD9: 340; ICD10:G35] Phase 1 [533005]
Company
Astellas Pharma Inc
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Modulator [533005]
Sphingosine 1-phosphate receptor 5 Target Info Modulator [533005]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04071:Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathways1p_s1p4_pathway:S1P4 pathway
S1P5 pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptorsR-HSA-418594:G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP26:Signal Transduction of S1P Receptor
References
Ref 533005ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. PLoS One. 2014 Oct 27;9(10):e110819.
Ref 533005ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. PLoS One. 2014 Oct 27;9(10):e110819.

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