Drug Information

Drug General Information
Drug ID
D0PL6T
Former ID
DNCL003818
Drug Name
RON Monoclonal Antibody
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [523034]
Company
Lilly
Target and Pathway
Target(s) RON Target Info Modulator [531006]
Pathway Interaction Database amb2 Integrin signaling
a6b1 and a6b4 Integrin signaling
References
Ref 523034ClinicalTrials.gov (NCT01119456) A Study of IMC-RON8 in Advanced Solid Tumors. U.S. National Institutes of Health.
Ref 531006Monoclonal antibody (mAb)-induced down-regulation of RON receptor tyrosine kinase diminishes tumorigenic activities of colon cancer cells. Int J Oncol. 2010 Aug;37(2):473-82.

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