Drug Information

Drug General Information
Drug ID
D0P9KA
Former ID
DIB016578
Drug Name
YM-16151-4
Synonyms
YM-151; YM-16151-1; (-)-YM-16151-1
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Phase 1 [533693]
Company
Yamanouchi Pharmaceutical Co Ltd
Formula
C30H37N3O9
Canonical SMILES
C1(=C(NC(=C(C1c1cc([N+](=O)[O-])ccc1OCCCCNCC(COc1ccccc1<br />)O)C(=O)OC)C)C)C(=O)OC.Cl
PubChem Compound ID
128387
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Modulator [533693]
Calcium channel Target Info Modulator [533693]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 533693Antianginal effects of YM-16151-4 in various experimental angina models. J Cardiovasc Pharmacol. 1993 May;21(5):701-8.
Ref 533693Antianginal effects of YM-16151-4 in various experimental angina models. J Cardiovasc Pharmacol. 1993 May;21(5):701-8.

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