Drug Information

Drug General Information
Drug ID
D0P3HG
Former ID
DIB020608
Drug Name
ONO-3708
Synonyms
BRN 4205392; ONO3708; ONO 3708
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539274]
Formula
C23H37NO4
InChI
InChI=1S/C23H37NO4/c1-23(2)16-13-18(23)17(11-5-3-4-6-12-20(25)26)19(14-16)24-22(28)21(27)15-9-7-8-10-15/h3,5,15-19,21,27H,4,6-14H2,1-2H3,(H,24,28)(H,25,26)/b5-3-/t16-,17+,18+,19+,21-/m1/s1
InChIKey
SXHUZJPIRVLMHY-AZPSIHDESA-N
PubChem Compound ID
5311334
PubChem Substance ID
7980202, 11056445, 12013821, 34951129, 49975629, 50779234, 53789398, 57359438, 103166982, 114155853, 135072532, 135650763, 198946959
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [533405]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539274(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1978).
Ref 533405Characterization of U46619 binding in unactivated, intact human platelets and determination of binding site affinities of four TXA2/PGH2 receptor antagonists (13-APA, BM 13.177, ONO 3708 and SQ 29,548). Thromb Res. 1986 Feb 15;41(4):471-81.

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