Drug Information

Drug General Information
Drug ID
D0OE0K
Former ID
DNC012098
Drug Name
3-Tetrazol-2-yl-1-aza-bicyclo[2.2.2]octane
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527344]
Formula
C8H13N5
Canonical SMILES
C1CN2CCC1C(C2)N3N=CN=N3
InChI
1S/C8H13N5/c1-3-12-4-2-7(1)8(5-12)13-10-6-9-11-13/h6-8H,1-5H2
InChIKey
AMJXIOSRIOJUEM-UHFFFAOYSA-N
PubChem Compound ID
15663667
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M4 Target Info Inhibitor [527344]
Muscarinic acetylcholine receptor M5 Target Info Inhibitor [527344]
Muscarinic acetylcholine receptor M3 Target Info Inhibitor [527344]
Muscarinic acetylcholine receptor M2 Target Info Inhibitor [527344]
Muscarinic acetylcholine receptor M1 Target Info Inhibitor [527344]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR downstream signaling
GPCRs, OtherWP706:SIDS Susceptibility Pathways
GPCRs, OtherWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
References
Ref 527344J Med Chem. 1992 Apr 3;35(7):1280-90.Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.
Ref 527344J Med Chem. 1992 Apr 3;35(7):1280-90.Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.

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