Drug Information

Drug General Information
Drug ID
D0O6WW
Former ID
DNC011669
Drug Name
8-Hydroxy-2-phenyl-3H-quinazolin-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534774]
Formula
C14H10N2O2
Canonical SMILES
C1=CC=C(C=C1)C2=NC(=O)C3=C(N2)C(=CC=C3)O
InChI
1S/C14H10N2O2/c17-11-8-4-7-10-12(11)15-13(16-14(10)18)9-5-2-1-3-6-9/h1-8,17H,(H,15,16,18)
InChIKey
JRDFYUFZPYBDNH-UHFFFAOYSA-N
PubChem Compound ID
10705079
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [534774]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 534774J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Ref 534774J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

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