Drug Information

Drug General Information
Drug ID
D0NN7D
Former ID
DNC000037
Drug Name
19-nor-10-azasteroid skeleton
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538023]
Formula
C10H13BrN6O3
Canonical SMILES
C1=NC2=C(C(=N1)N)C(=NN2C3C(C(C(O3)CN)O)O)Br
InChI
1S/C10H13BrN6O3/c11-7-4-8(13)14-2-15-9(4)17(16-7)10-6(19)5(18)3(1-12)20-10/h2-3,5-6,10,18-19H,1,12H2,(H2,13,14,15)/t3-,5-,6-,10-/m1/s1
InChIKey
LTTBFVDMHCIDPM-BHBWVORQSA-N
CAS Number
CAS 144928-48-3
PubChem Compound ID
132663
PubChem Substance ID
7979329, 10243166, 14851707, 29310760, 57344228, 77197593, 103385858, 104025276, 104377975, 134339583, 134340063, 135089509, 142958397, 228201813, 246904686
Target and Pathway
Target(s) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 Target Info Inhibitor [538023]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Target Info Inhibitor [538023]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Allopregnanolone biosynthesis
Androgen biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
Androgen biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Prostate cancerhsa00140:Steroid hormone biosynthesis
NetPath Pathway IL2 Signaling Pathway
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome Androgen biosynthesisR-HSA-193048:Androgen biosynthesis
References
Ref 53802319-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem. 1997 Mar 28;40(7):1112-29.
Ref 53802319-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem. 1997 Mar 28;40(7):1112-29.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.