Drug Information

Drug General Information
Drug ID
D0NI4Z
Former ID
DNC004186
Drug Name
7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528087]
Formula
C10H6ClN3O
Canonical SMILES
C1=CC2=NC3=C(C=C2C=C1Cl)NC(=O)N3
InChI
1S/C10H6ClN3O/c11-6-1-2-7-5(3-6)4-8-9(12-7)14-10(15)13-8/h1-4H,(H2,12,13,14,15)
InChIKey
OSBMKBWTTUTUMA-UHFFFAOYSA-N
PubChem Compound ID
13936972
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [528087]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
cAMP signaling pathway
Morphine addiction
Reactome cGMP effects
G alpha (s) signalling events
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 528087J Med Chem. 1991 Sep;34(9):2906-16.1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.
Ref 528087J Med Chem. 1991 Sep;34(9):2906-16.1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.

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