TTD | Drug: D0NH6Q

Drug General Information
Drug ID	D0NH6Q
Former ID	DIB020429
Drug Name	MRS2365
Synonyms	(N)-methanocarba-2-MeSADP; MRS 2365
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540297]
Formula	C13H16N5Na3O9P2S
InChI	InChI=1S/C13H19N5O9P2S.3Na/c1-30-12-16-10(14)6-11(17-12)18(4-15-6)7-5-2-13(5,9(20)8(7)19)3-26-29(24,25)27-28(21,22)23;;;/h4-5,7-9,19-20H,2-3H2,1H3,(H,24,25)(H2,14,16,17)(H2,21,22,23);;;/q;3*+1/p-3/t5-,7?,8+,9+,13+;;;/m1.../s1
InChIKey	ZYPJOXVKTCEBCA-PVMCGCOJSA-K
PubChem Compound ID	73755043
PubChem Substance ID	57309877, 178100369
Target and Pathway
Target(s)	P2Y purinoceptor 1	Target Info	Agonist	[527201]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	G alpha (q) signalling events
	P2Y receptors
	ADP signalling through P2Y purinoceptor 1
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540297	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3338).
Ref 527201	Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J Pharmacol Exp Ther. 2004Dec;311(3):1038-43. Epub 2004 Sep 2.

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Drug Information