Drug Information

Drug General Information
Drug ID
D0N7MS
Former ID
DIB018743
Drug Name
ACAA
Synonyms
ACA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539571]
Formula
C21H23NO3
InChI
InChI=1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+
InChIKey
GAMRBCZMOOMBSQ-CCEZHUSRSA-N
PubChem Compound ID
5353376
PubChem Substance ID
11651278, 15075387, 26758124, 39379601, 48035243, 57361529, 77713242, 85787189, 103430866, 113909119, 135087133, 135649885, 135653606, 137144799, 162093646, 163688704, 172876345, 204365669, 225100345
Target and Pathway
Target(s) TRPM8 protein Target Info Blocker (channel blocker) [543859]
Short transient receptor potential channel 6 Target Info Blocker (channel blocker) [543855]
Long transient receptor potential channel 2 Target Info Blocker (channel blocker) [528125]
Short transient receptor potential channel 3 Target Info Blocker (channel blocker) [543852]
KEGG Pathway Inflammatory mediator regulation of TRP channels
PANTHER Pathway Alzheimer disease-presenilin pathway
Pathway Interaction Database Endothelins
Nephrin/Neph1 signaling in the kidney podocyte
EPO signaling pathway
PAR1-mediated thrombin signaling eventspi3kplctrkpathway:Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channelsR-HSA-114508:Effects of PIP2 hydrolysis
TRP channels
Role of second messengers in netrin-1 signalingR-HSA-3295583:TRP channelsR-HSA-114508:Effects of PIP2 hydrolysis
Role of second messengers in netrin-1 signaling
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
Platelet homeostasis
Netrin-1 signaling
GPCR downstream signaling
Effects of PIP2 hydrolysisWP1885:Platelet homeostasis
Effects of PIP2 hydrolysis
References
Ref 539571(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2443).
Ref 528125Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73.
Ref 543852(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488).
Ref 543855(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491).
Ref 543859(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500).

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