Drug Information

Drug General Information
Drug ID
D0N4PZ
Former ID
DNC000794
Drug Name
Incadronate
Drug Type
Small molecular drug
Indication Hypercalcemia [ICD9: 275.42; ICD10:E83.5] Approved [551871]
Formula
C8H17NNa2O6P2
Canonical SMILES
C1CCCC(CC1)NC(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
InChI
1S/C8H19NO6P2.2Na/c10-16(11,12)8(17(13,14)15)9-7-5-3-1-2-4-6-7;;/h7-9H,1-6H2,(H2,10,11,12)(H2,13,14,15);;/q;2*+1/p-2
InChIKey
PCSJAAWOSGCAFV-UHFFFAOYSA-L
CAS Number
CAS 61413-54-5
PubChem Compound ID
6918123
PubChem Substance ID
12014398, 14875230, 17194688, 43529518, 57371810, 74711443, 114787471, 134340120, 162176928, 163134170, 204375476, 241033836
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [535102]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535102Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42.

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