Drug Information

Drug General Information
Drug ID
D0N3XP
Former ID
DIB019890
Drug Name
G749
Synonyms
G-749
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532674]
Formula
C25H25BrN6O2
InChI
InChI=1S/C25H25BrN6O2/c1-32-13-11-17(12-14-32)29-25-30-22-20(26)15-27-24(33)21(22)23(31-25)28-16-7-9-19(10-8-16)34-18-5-3-2-4-6-18/h2-10,15,17H,11-14H2,1H3,(H,27,33)(H2,28,29,30,31)
InChIKey
SXWMIXPJPNCXQQ-UHFFFAOYSA-N
PubChem Compound ID
78357765
PubChem Substance ID
210274795, 210280428, 223405843, 223427128, 240219313, 249565788, 249714998, 251910687, 252451826, 252470223
Target and Pathway
Target(s) Mertk Target Info Inhibitor [532674]
FL cytokine receptor Target Info Inhibitor [532674]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
NetPath Pathway TSH Signaling Pathway
Reactome Cell surface interactions at the vascular wall
WikiPathways Cell surface interactions at the vascular wall
References
Ref 532674G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia. Blood. 2014 Apr 3;123(14):2209-19.
Ref 532674G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia. Blood. 2014 Apr 3;123(14):2209-19.

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