Drug Information

Drug General Information
Drug ID
D0MP8E
Former ID
DIB021203
Drug Name
VUF 8430
Synonyms
VUF8430; VUF-8430
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538788]
Formula
C4H11N5S
InChI
InChI=1S/C4H11N5S/c5-3(6)9-1-2-10-4(7)8/h1-2H2,(H3,7,8)(H4,5,6,9)
InChIKey
GSYGTVNTZHFQQH-UHFFFAOYSA-N
PubChem Compound ID
3063228
PubChem Substance ID
36127955, 50112879, 79561405, 111646611, 124968863, 135262187, 135651314, 137143458, 163368467, 247163341
Target and Pathway
Target(s) Histamine H4 receptor Target Info Agonist [528567]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538788(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1274).
Ref 528567Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem. 2006 Nov 16;49(23):6650-1.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.