Drug Information

Drug General Information
Drug ID
D0M8UY
Former ID
DNC009264
Drug Name
6-hydroxybenzo[d][1,3]oxathiol-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529555]
Formula
C7H4O3S
Canonical SMILES
C1=CC2=C(C=C1O)OC(=O)S2
InChI
1S/C7H4O3S/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3,8H
InChIKey
SLYPOVJCSQHITR-UHFFFAOYSA-N
PubChem Compound ID
72139
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [529555]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 529555Bioorg Med Chem Lett. 2008 Jul 15;18(14):3938-41. Epub 2008 Jun 12.Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?.
Ref 529555Bioorg Med Chem Lett. 2008 Jul 15;18(14):3938-41. Epub 2008 Jun 12.Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?.

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