Drug Information

Drug General Information
Drug ID
D0M4PH
Former ID
DIB009174
Drug Name
LOXO-101
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [524734]
Company
Array biopharma; loxo oncology
Target and Pathway
Target(s) BDNF/NT-3 growth factors receptor Target Info Inhibitor [543504]
Trk receptor Target Info Inhibitor [532994]
Neurotrophic tyrosine kinase receptor 1 Target Info Inhibitor [551954]
KEGG Pathway MAPK signaling pathway
Neurotrophin signaling pathway
Alcoholismhsa04010:MAPK signaling pathway
Endocytosis
Apoptosis
Inflammatory mediator regulation of TRP channels
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
Central carbon metabolism in cancer
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database SHP2 signaling
Posttranslational regulation of adherens junction stability and dissassembly
Neurotrophic factor-mediated Trk receptor signalingtrkrpathway:Neurotrophic factor-mediated Trk receptor signaling
Reactome NGF-independant TRKA activationR-HSA-170984:ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activationR-HSA-170968:Frs2-mediated activation
ARMS-mediated activation
PI3K/AKT activation
WikiPathways SIDS Susceptibility Pathways
BDNF signaling pathwayWP382:MAPK Signaling Pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
NGF signalling via TRKA from the plasma membraneWP382:MAPK Signaling Pathway
NGF signalling via TRKA from the plasma membrane
References
Ref 524734ClinicalTrials.gov (NCT02122913) Oral TRK Inhibitor LOXO-101 for Treatment of Advanced Adult Solid Tumors. U.S. National Institutes of Health.
Ref 532994ALK inhibitors in non-small cell lung cancer: crizotinib and beyond. Clin Adv Hematol Oncol. 2014 Jul;12(7):429-39.
Ref 543504(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818).
Ref 551954Clinical pipeline report, company report or official report of Loxo Oncology.

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