Drug Information

Drug General Information
Drug ID
D0LM8L
Former ID
DNC010662
Drug Name
N-[(4-bromo-1-benzothien-3-yl)methyl]sulfamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530089]
Formula
C9H9BrN2O2S2
Canonical SMILES
C1=CC2=C(C(=C1)Br)C(=CS2)CNS(=O)(=O)N
InChI
1S/C9H9BrN2O2S2/c10-7-2-1-3-8-9(7)6(5-15-8)4-12-16(11,13)14/h1-3,5,12H,4H2,(H2,11,13,14)
InChIKey
FBZAPOBZDNKPQH-UHFFFAOYSA-N
PubChem Compound ID
11623927
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [530089]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 530089J Med Chem. 2009 Dec 10;52(23):7528-36.Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.
Ref 530089J Med Chem. 2009 Dec 10;52(23):7528-36.Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

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