Drug Information

Drug General Information
Drug ID
D0L5YF
Former ID
DIB010867
Drug Name
ZD-4190
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Terminated [546662]
Company
AstraZeneca plc
Formula
C19H17BrClFN6O2
Canonical SMILES
c12c(Nc3c(cc(cc3)Br)F)ncnc1cc(c(c2)OC)OCCn1nncc1.Cl
CAS Number
CAS 257938-36-6
PubChem Compound ID
6918394
Target and Pathway
Target(s) VEGF receptor Target Info Modulator [525712]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritis
References
Ref 546662Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009540)
Ref 525712ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy. Cancer Res. 2000 Feb 15;60(4):970-5.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.