Drug Information

Drug General Information
Drug ID
D0L2ZY
Former ID
DNCL002239
Drug Name
X-82
Indication Advanced solid tumor; Macular degeneration [ICD9: 140-199, 362.5; ICD10:C00-C75, C7A, C7B, H35.3] Phase 1 [551750]
Company
Tyrogenex West Palm Beach
Target and Pathway
Target(s) Platelet-derived growth factor receptor Target Info Modulator [550468]
Vascular endothelial growth factor receptor 1 Target Info Modulator [550468]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritis
Pathway Interaction Database Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
VEGF and VEGFR signaling network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Focal Adhesion
Signaling by VEGF
Angiogenesis
References
Ref 551750Clinical pipeline report, company report or official report of Tyrogenex.
Ref 550468National Cancer Institute Drug Dictionary (drug id 695817).

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