Drug Information

Drug General Information
Drug ID
D0K8PH
Former ID
DIB002724
Drug Name
SUVN-504
Synonyms
SUVN-503; SUVN-51005; M1 of SUVN-507, Suven; 5-HT 6 antagonists (emesis), Suven; 5-HT 6 antagonists (obesity), Suven
Indication Emesis [ICD9: 787; ICD10:R11] Investigative [543365]
Company
Suven Life Sciences Ltd
Canonical SMILES
O=S(=O)(N1C2CC(C=CC2C=C1)OC)c1ccc(cc1OCC1CCN(CC1)C)Cl
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [543365]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 543365(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11).
Ref 543365(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.