Drug Information

Drug General Information
Drug ID
D0K6DG
Former ID
DIB006795
Drug Name
ONO-8130
Synonyms
Pollakiuria agent, Ono
Indication Pollakiuria [ICD10:R35] Terminated [547730]
Company
Ono Pharmaceutical Co Ltd
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP1 subtype Target Info Modulator [531389]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Pathways in cancer
PANTHER Pathway PI3 kinase pathway
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 547730Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018852)
Ref 531389ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain. 2011 Jun;152(6):1373-81.

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