Drug Information

Drug General Information
Drug ID
D0K5WM
Former ID
DIB009595
Drug Name
CS-3030
Synonyms
R-142086; Factor Xa inhibitor (DVT/ pulmonary embolism), Daiichi Sankyo; Factor Xa inhibitor (DVT/ pulmonary embolism), Sankyo; Factor Xa inhibitor (deep vein thrombosis/ pulmonary embolism), Daiichi Sankyo; Factor Xa inhibitor (deep vein thrombosis/ pulmonary embolism), Sankyo
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Preclinical [548159]
Company
Daiichi-Sankyo
Canonical SMILES
Cl.Cl.O=S(=O)(N(C/C(=C/c1cc(ccc1)C(=N)N)/F)c1cc(c(cc1)O<br />C1CCN(CC1)C(=N)C)C(=O)N)CC(=O)O
Target and Pathway
Target(s) Coagulation factor Xa Target Info Inhibitor [531405], [531982]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
Pathway Interaction Database Beta2 integrin cell surface interactions
PathWhiz Pathway Coagulation
Reactome Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
Human Complement System
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 548159Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022617)
Ref 531405Venous thromboembolism in the patient with cancer: focus on burden of disease and benefits of thromboprophylaxis. Cancer. 2011 Apr 1;117(7):1334-49.
Ref 531982Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7.

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