Drug Information

Drug General Information
Drug ID
D0K5ME
Former ID
DIB020210
Drug Name
levetimide
Synonyms
(-)-benzetimide; l-benzetimide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540476]
Formula
C23H26N2O2
InChI
InChI=1S/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)/t23-/m0/s1
InChIKey
LQQIVYSCPWCSSD-QHCPKHFHSA-N
PubChem Compound ID
30844
PubChem Substance ID
24538415, 34673041, 47731326, 48404550, 49973059, 57311003, 77427309, 103929654, 104309268, 134995278, 135123913, 135650514, 137267316, 139183645, 162180642, 180372154, 184528992, 198986806, 227840205, 247656348, 252165314
Target and Pathway
Target(s) Muscarinic receptor Target Info Antagonist [534549]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540476(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 358).
Ref 534549Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line. J Pharmacol Exp Ther. 1998 Feb;284(2):500-7.

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