Drug Information

Drug General Information
Drug ID
D0K5HI
Former ID
DCL000241
Drug Name
Talnetant
Synonyms
Talnetant [INN]; SB 223412; SB-223412; N-((S)-alpha-Ethylbenzyl)-3-hydroxy-2-phenylcinchoninamide;N-(alpha-Ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide; 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
Drug Type
Small molecular drug
Indication Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1] Discontinued in Phase 2 [536224], [539353]
Schizophrenia; Schizoaffective disorders [ICD9: 295, 295.70; ICD10:F20, F25] Discontinued in Phase 2 [536224], [539353]
Company
GlaxoSmithKline
Formula
C25H22N2O2
InChI
InChI=1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1
InChIKey
BIAVGWDGIJKWRM-FQEVSTJZSA-N
CAS Number
CAS 174636-32-9
PubChem Compound ID
5311424
PubChem Substance ID
7980568, 11056495, 14755991, 14780225, 39341100, 57304378, 57359475, 78070082, 103169903, 103948291, 114156058, 127518680, 135650992, 136368156, 143156201, 198973884, 208265371, 210275099, 210280738, 223490643, 223760301, 226454082, 241377116, 249684590, 252158262, 252481164
Target and Pathway
Target(s) Nigral tachykinin NK(3) receptor Target Info Antagonist [536865], [536894], [537495]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536224Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
Ref 539353(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2132).
Ref 536865Augmentation of antipsychotic-induced neurochemical changes by the NK3 receptor antagonist talnetant (SB-223412). Neuropharmacology. 2009 Feb;56(2):342-9. Epub 2008 Sep 18.
Ref 536894The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. Epub 2008 Oct 10.
Ref 537495Pharmacological characterization of senktide-induced tail whips. Neuropharmacology. 2009 Jun 21.

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