Drug Information

Drug General Information
Drug ID
D0K0QU
Former ID
DNC009192
Drug Name
(+)-(5S,8S,10S)-20-methoxypuupehenol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526556]
Formula
C23H34O4
Canonical SMILES
CC1(CCCC2(C1CCC3(C2C(C4=CC(=C(C=C4O3)O)OC)OC)C)C)C
InChI
1S/C23H34O4/c1-21(2)9-7-10-22(3)18(21)8-11-23(4)20(22)19(26-6)14-12-17(25-5)15(24)13-16(14)27-23/h12-13,18-20,24H,7-11H2,1-6H3/t18-,19+,20+,22-,23-/m0/s1
InChIKey
JAGJWSBNJZPDNL-FCSJJDFTSA-N
PubChem Compound ID
11740143
Target and Pathway
Target(s) Arachidonate 15-lipoxygenase Target Info Inhibitor [526556]
Arachidonate 12-lipoxygenase, 12S-type Target Info Inhibitor [526556]
BioCyc Pathway Resolvin D biosynthesis
Lipoxin biosynthesisPWY66-392:Lipoxin biosynthesis
KEGG Pathway Arachidonic acid metabolism
Linoleic acid metabolism
Metabolic pathways
Serotonergic synapsehsa00590:Arachidonic acid metabolism
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL4-mediated signaling events
PathWhiz Pathway Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid SynthesisWP2650:Arachidonic acid metabolism
Eicosanoid Synthesis
References
Ref 526556J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
Ref 526556J Nat Prod. 2003 Feb;66(2):230-5.Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.

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