Drug Information

Drug General Information
Drug ID
D0JJ8A
Former ID
DIB016286
Drug Name
CaV2.2 blocker
Synonyms
CaV2.2 blocker (pain); CaV2.2 blocker (pain), Merck & Co
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [552036]
Company
Merck & Co Inc
Canonical SMILES
CC(C)(S(=O)(=O)c1cc(cc(C(F)(F)F)c1)F)C1CCN(C(=O)c2ncc(C<br />(F)(F)F)cc2S(=O)(=O)C)CC1
Target and Pathway
Target(s) Voltage-dependent N-type calcium channel Target Info Blocker [543870]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Taste transduction
Type II diabetes mellitus
Morphine addiction
Nicotine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Thyrotropin-releasing hormone receptor signaling pathway
Endogenous cannabinoid signaling
GABA-B receptor II signaling
Reactome Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
WikiPathways Calcium Regulation in the Cardiac Cell
Synaptic Vesicle Pathway
References
Ref 552036A high-throughput assay for evaluating state dependence and subtype selectivity of Cav2 calcium channel inhibitors. Assay Drug Dev Technol. 2008 Apr;6(2):195-212
Ref 543870(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 533).

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