Drug Information

Drug General Information
Drug ID
D0J9UI
Former ID
DNC001526
Drug Name
YM60828
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546601]
Formula
C27H31N5O5S
Canonical SMILES
CC(=N)N1CCC(CC1)OC2=CC=C(C=C2)N(CC3=CC4=C(C=C3)C=CC(=C4<br />)C(=N)N)S(=O)(=O)CC(=O)O
InChI
1S/C27H31N5O5S/c1-18(28)31-12-10-25(11-13-31)37-24-8-6-23(7-9-24)32(38(35,36)17-26(33)34)16-19-2-3-20-4-5-21(27(29)30)15-22(20)14-19/h2-9,14-15,25,28H,10-13,16-17H2,1H3,(H3,29,30)(H,33,34)
InChIKey
NPBKHEMDWREFJJ-UHFFFAOYSA-N
CAS Number
CAS 201933-41-7
PubChem Compound ID
9807238
PubChem Substance ID
14763384, 24114678, 39901991, 44843231, 80358697, 103187104, 103984151, 134340690, 134351794, 136014155, 140123543, 160643856, 164235521, 172919910, 226972099
Target and Pathway
Target(s) Coagulation factor Xa Target Info Inhibitor [535352]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
Pathway Interaction Database Beta2 integrin cell surface interactions
PathWhiz Pathway Coagulation
Reactome Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
Human Complement System
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 546601Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009133)
Ref 535352Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32.

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