Drug Information

Drug General Information
Drug ID
D0J8RR
Former ID
DCL000773
Drug Name
Dextromethorphan+quinidine
Drug Type
Small molecular drug
Indication Painful diabetic neuropathy [ICD9: 250.6,338,780; ICD10:E10.4, E11.4, E13.4, G89, R52] Phase 2 [536078]
Company
Avanir
Formula
C18H28BrNO2
PubChem Compound ID
5462351
Target and Pathway
Target(s) Cytochrome P450 19 Target Info Inhibitor [536374]
NMDA receptor Target Info Antagonist [536374]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis II
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome Endogenous sterols
WikiPathways Metapathway biotransformation
Tryptophan metabolism
Oxidation by Cytochrome P450
Ovarian Infertility Genes
Metabolism of steroid hormones and vitamin D
FSH signaling pathway
Integrated Breast Cancer Pathway
Phase 1 - Functionalization of compounds
References
Ref 536078Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7.
Ref 536374Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.

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