Drug Information

Drug General Information
Drug ID
D0IF3N
Former ID
DIB020467
Drug Name
N,N-dimethylhistamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538785]
Formula
C7H13N3
InChI
InChI=1S/C7H13N3/c1-10(2)4-3-7-5-8-6-9-7/h5-6H,3-4H2,1-2H3,(H,8,9)
InChIKey
ZJDIMSMQXMWMCF-UHFFFAOYSA-N
PubChem Compound ID
12656
PubChem Substance ID
10532396, 15041383, 24506573, 29280862, 49979535, 57327749, 74686742, 85230023, 92729690, 103173262, 104329604, 129910210, 132632305, 134978107, 135650400, 162631903, 227469000, 249923193
Target and Pathway
Target(s) Histamine H4 receptor Target Info Agonist [527985]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538785(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1270).
Ref 527985Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br J Pharmacol. 2006 Apr;147(7):744-54.

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