Drug Information

Drug General Information
Drug ID
D0I9VO
Former ID
DCL000799
Drug Name
Epratuzumab
Synonyms
LymphoCide; Lymphocide (TN); Epratuzumab (USAN/INN)
Drug Type
Antibody
Indication Systemic lupus erythematosus; Graft rejection in heart transplantation [ICD9: 695, 710.0, 996; ICD10:L51-L54, M32, T86] Phase 3 [537129], [542963]
Company
Immunomedics
CAS Number
CAS 205923-57-5
PubChem Substance ID
47206001
Target and Pathway
Target(s) B-cell receptor CD22 Target Info [537129]
KEGG Pathway Cell adhesion molecules (CAMs)
Hematopoietic cell lineage
B cell receptor signaling pathway
PANTHER Pathway B cell activation
Pathway Interaction Database BCR signaling pathway
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways B Cell Receptor Signaling Pathway
References
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
Ref 542963(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8088).
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.

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