Drug Information

Drug General Information
Drug ID
D0I9QH
Former ID
DIB000179
Drug Name
SR-58878
Indication Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1] Terminated [549821]
Company
Sanofi-Synthelabo
Canonical SMILES
c12c(ccc(c1)OCC(=O)O)CC[C@@H](C2)NC[C@H](c1cc(Cl)ccc1)O
CAS Number
CAS 191533-25-2
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [543754]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 549821Clinical pipeline report, company report or official report of Sanofi-Synthelabo.
Ref 543754(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 30).

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