TTD | Drug: D0I5LM

Drug General Information
Drug ID	D0I5LM
Former ID	DIB002145
Drug Name	R-1065
Synonyms	VR-1065; Ro-60-0332
Indication	Obesity [ICD9: 278; ICD10:E66]		Discontinued in Phase 1	[547560]
Company	Vernalis Group plc
Canonical SMILES	c12c(n(cc2)C[C@@H](N)C)c2c(C1(C)C)ccc(c2)C.C(=O)(/C=C/C<br />(=O)O)O
Target and Pathway
Target(s)	5-hydroxytryptamine 2C receptor	Target Info	Agonist	[534693]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 547560	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017316)
Ref 534693	Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats. Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.

Drug Information