Drug Information

Drug General Information
Drug ID
D0I3PG
Former ID
DIB005978
Drug Name
SDZ-CPI-975
Synonyms
CPT inhibitors, Sandoz; Carnitine palmitoyl transferase I inhbitors, Sandoz; SDZ-267-894
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Discontinued in Phase 1 [545960]
Company
Sandoz Research Institute
Canonical SMILES
P(=O)(O[C@H](CC(=O)O)[N+](C)(C)C)([O-])OCCCCCCCCCCCCCC
CAS Number
CAS 157244-53-6
Target and Pathway
Target(s) Carnitine O-palmitoyltransferase I Target Info Inhibitor [534566]
KEGG Pathway Fatty acid degradation
Fatty acid metabolism
PPAR signaling pathway
AMPK signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
PathWhiz Pathway Fatty acid Metabolism
Reactome RORA activates gene expression
PPARA activates gene expression
Import of palmitoyl-CoA into the mitochondrial matrix
WikiPathways SIDS Susceptibility Pathways
Mitochondrial LC-Fatty Acid Beta-Oxidation
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Fatty Acid Beta Oxidation
AMPK Signaling
References
Ref 545960Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005522)
Ref 534566Hypoglycemic effects of a novel fatty acid oxidation inhibitor in rats and monkeys. Am J Physiol. 1998 Feb;274(2 Pt 2):R524-8.

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