Drug Information

Drug General Information
Drug ID
D0I3IO
Former ID
DNC005977
Drug Name
6-(4-fluorostyryl)-2-morpholino-4H-chromen-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527888]
Formula
C21H18FNO3
Canonical SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C=CC(=C3)C=CC4=CC=C(C=C4)F
InChI
1S/C21H18FNO3/c22-17-6-3-15(4-7-17)1-2-16-5-8-20-18(13-16)19(24)14-21(26-20)23-9-11-25-12-10-23/h1-8,13-14H,9-12H2/b2-1+
InChIKey
MGIIGLFUKQWDHF-OWOJBTEDSA-N
PubChem Compound ID
11717289
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [527888]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.

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