Drug Information

Drug General Information
Drug ID
D0I2AV
Former ID
DAP000384
Drug Name
Tositumomab
Synonyms
Bexxar (TN)
Drug Type
Antibody
Indication Non-hodgkin's lymphoma [ICD10:C85] Approved [536361], [541861]
Therapeutic Class
Anticancer Agents
Company
GlaxoSmithKline
Formula
C6416H9874N1688O1987S44
CAS Number
CAS 192391-48-3
Target and Pathway
Target(s) B-lymphocyte antigen CD20 Target Info [537294]
KEGG Pathway Hematopoietic cell lineage
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541861(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6781).
Ref 537294Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20. Mol Immunol. 2009 Jul;46(11-12):2419-23. Epub 2009 May 8.

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