Drug Information

Drug General Information
Drug ID
D0I0VK
Former ID
DNC000660
Drug Name
FR149175
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Terminated [546562]
Formula
C11H22O2
Canonical SMILES
CCCCCCC(CCC)C(=O)O
InChI
1S/C11H22O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h10H,3-9H2,1-2H3,(H,12,13)/t10-/m1/s1
InChIKey
YCYMCMYLORLIJX-SNVBAGLBSA-N
CAS Number
CAS 185517-21-9
PubChem Compound ID
208925
PubChem Substance ID
9368737, 12015175, 15171440, 15195263, 30413566, 47207953, 57399566, 78156578, 103066752, 103079595, 113442118, 117541332, 124894576, 129777841, 132572103, 134339356, 134340030, 135183048, 135694756, 137061534, 142551269, 144206875, 162254961, 162807354, 163413958, 163884615, 164835957, 172859255, 175426981, 180371084, 198967322, 223545538, 224174346, 226396378, 242590696, 252158144, 252513052
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [538035]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 546562Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008959)
Ref 538035FR149175, a beta 3-adrenoceptor-selective agonist, is a possible therapeutic agent for non-insulin-dependent diabetes mellitus. Jpn J Pharmacol. 1997 May;74(1):109-12.

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