Drug Information

Drug General Information
Drug ID
D0HP1O
Drug Name
AF-DX-384
Synonyms
AF-DX-384; 118290-27-0; AF-DX-384
Drug Type
Small molecular drug
Indication Unspecified Investigative [1560197], [1560396]
Formula
C27H38N6O2
PubChem Compound ID
119357
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M4 Target Info Modulator
Muscarinic acetylcholine receptor M2 Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, Other
References
Ref 1560197M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site.
Ref 1560396M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.