Drug Information

Drug General Information
Drug ID
D0H7PC
Former ID
DNC003592
Drug Name
SB-357134
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540210]
Formula
C17H18Br2FN3O3S
InChI
InChI=1S/C17H18Br2FN3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(20)17(14)19/h2-3,8-10,21-22H,4-7H2,1H3
InChIKey
BLWHAZZXRHTFJE-UHFFFAOYSA-N
PubChem Compound ID
6918553
PubChem Substance ID
12015478, 14860749, 17194956, 43529923, 48105236, 48404520, 52191879, 57371972, 85226460, 103308306, 104021702, 114788158, 127534481, 134340797, 135651006, 137010138, 142034485, 162223694, 226973395
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [529191]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540210(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3235).
Ref 529191Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. Epub 2007 Nov 17.Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.

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