Drug Information

Drug General Information
Drug ID
D0H5LC
Former ID
DIB008711
Drug Name
CHPMPC
Synonyms
Cyclic HPMPC; Cyclic cidofovir; Cidofovir prodrug, Gilead; GS-504 analog; GS-930
Drug Type
Small molecular drug
Indication Viral infections [ICD9: 054.0, 054.1, 054.2, 054.3, 075, 771.2, 052, 053; ICD10:B01, B02, A60, B00, B27, G05.1, P35.2] Discontinued in Phase 1 [545808]
Company
Gilead Sciences Inc
Formula
C8H12N3O5P
Canonical SMILES
n1c(=O)n(ccc1N)C[C@H]1OCP(=O)(OC1)O
CAS Number
CAS 127757-45-3
PubChem Compound ID
122873
Target and Pathway
Target(s) DNA polymerase Target Info Modulator [544014]
References
Ref 545808Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004825)
Ref 544014Conversion of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase.. Antimicrob Agents Chemother. 1997 March; 41(3): 641-646.

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