Drug Information

Drug General Information
Drug ID
D0H2YM
Former ID
DIB018537
Drug Name
27-hydroxycholesterol
Synonyms
27-OHC; 26-hydroxycholesterol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539797]
Formula
C27H46O2
InChI
InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKey
FYHRJWMENCALJY-YSQMORBQSA-N
PubChem Compound ID
123976
PubChem Substance ID
7983972, 10240936, 14781421, 16838026, 29304136, 49688258, 57340689, 57394505, 76719767, 99300562, 103114810, 103430526, 104419794, 126524357, 135079884, 135651393, 137116110, 171572123, 179662087, 184590326, 198985423, 223721328, 223752559, 226631926, 241038309, 246253752
Target and Pathway
Target(s) GPR183 Target Info Agonist [531581]
Oxysterols receptor LXR-alpha Target Info Agonist [526122]
Oxysterols receptor LXR-beta Target Info Agonist [526122]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear ReceptorsWP1982:SREBP signalling
Nuclear Receptors
References
Ref 539797(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2752).
Ref 52612227-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem. 2001 Oct 19;276(42):38378-87. Epub 2001 Aug 14.
Ref 531581Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.

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