Drug Information

Drug General Information
Drug ID
D0H0EQ
Former ID
DNAP001678
Drug Name
Ponatinib
Synonyms
Iclusig (TN); Tyrosine Kinase Inhibitor - Ns
Drug Type
Small molecular drug
Indication Acute lymphoblastic leukemia [ICD9: 204.0, 556; ICD10:C91.0] Approved [532210], [541188]
Company
ARIAD Pharmaceuticals
Formula
C29H27F3N6O
InChI
InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
InChIKey
PHXJVRSECIGDHY-UHFFFAOYSA-N
CAS Number
CAS 943319-70-8
PubChem Compound ID
24826799
PubChem Substance ID
49848164, 57136216, 85267726, 85267727, 99437188, 103162345, 103768137, 104144064, 124757292, 125164096, 131480900, 135263267, 135626676, 135727465, 136350016, 136367447, 136368095, 136920265, 137245313, 137275996, 139832791, 144115614, 152134633, 152146116, 152258369, 160644559, 160647206, 162011539, 162037632, 162164010, 162164012, 162201514, 163209942, 164043013, 164187223, 164834148, 170503740, 172087035, 174006583, 174531620, 175266091, 175427142, 177749778, 178102513, 180371706, 185988972, 188899573, 196408591, 198993325, 204380154
SuperDrug ATC ID
L01XE24
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) FL cytokine receptor Target Info Modulator [551871]
Proto-oncogene c-Abl Target Info Modulator [551871]
Mast/stem cell growth factor receptor Target Info Modulator [551871]
Proto-oncogene tyrosine-protein kinase receptor ret Target Info Modulator [551871]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancerhsa04012:ErbB signaling pathway
Ras signaling pathway
Cell cycle
Axon guidance
Neurotrophin signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
MicroRNAs in cancer
Chronic myeloid leukemia
Viral myocarditishsa04014:Ras signaling pathway
Rap1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Melanogenesis
Central carbon metabolism in cancerhsa04144:Endocytosis
Thyroid cancer
Central carbon metabolism in cancer
NetPath Pathway IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling Pathway
PANTHER Pathway Axon guidance mediated by Slit/Robo
Pathway Interaction Database p73 transcription factor network
ATM pathway
Regulation of Telomerase
Posttranslational regulation of adherens junction stability and dissassembly
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-beta signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Regulation of retinoblastoma proteincmyb_pathway:C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)ret_pathway:Signaling events regulated by Ret tyrosine kinase
Reactome Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Factors involved in megakaryocyte development and platelet productionR-HSA-1257604:PIP3 activates AKT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
WikiPathways Apoptosis-related network due to altered Notch3 in ovarian cancer
Fcgamma receptor (FCGR) dependent phagocytosis
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Pathogenic Escherichia coli infection
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
Signaling by Robo receptor
Myogenesis
Factors involved in megakaryocyte development and platelet productionWP304:Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP706:SIDS Susceptibility Pathways
Dopaminergic Neurogenesis
References
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 541188(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5890).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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