Drug Information

Drug General Information
Drug ID
D0GP4R
Former ID
DIB013911
Drug Name
Picumeterol
Synonyms
Levopicumeterol; Picumeterol fumarate; GX 63411; GR-114297; GR-114297A; GR-114297X; GR-63411
Drug Type
Small molecular drug
Indication Bronchodilator [ICD9: 493; ICD10:J45] Discontinued in Phase 2 [545347]
Company
Glaxo Wellcome plc
Formula
C25H33Cl2N3O6
Canonical SMILES
c1(c(cc(cc1Cl)[C@@H](O)CNCCCCCCOCCc1ncccc1)Cl)N
PubChem Compound ID
9828766
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [534374]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 545347Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002942)
Ref 534374Picumeterol: dissociation of improvement in lung function and reduction of airways hyperresponsiveness in asthmatics. Br J Clin Pharmacol. 1997 Feb;43(2):169-76.

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