Drug Information

Drug General Information
Drug ID
D0G8KA
Former ID
DIB020690
Drug Name
Pfizer compound 11
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529445], [541124]
Formula
C24H18ClF3N4O3
InChI
InChI=1S/C24H18ClF3N4O3/c1-15-14-22(32(31-15)20-8-4-2-6-18(20)25)34-21-9-5-3-7-19(21)30-23(33)29-16-10-12-17(13-11-16)35-24(26,27)28/h2-14H,1H3,(H2,29,30,33)
InChIKey
SAIPZPCGTLOMFE-UHFFFAOYSA-N
PubChem Compound ID
24958668
PubChem Substance ID
56256538, 57487599, 103563510, 141846860, 160852424, 178102429, 198962316, 223370249, 224218106, 230790802, 246718833
Target and Pathway
Target(s) P2Y purinoceptor 1 Target Info Antagonist [529445]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 529445Bioorg Med Chem Lett. 2008 Jun 1;18(11):3338-43. Epub 2008 Apr 15.P2Y1 receptor antagonists as novel antithrombotic agents.
Ref 541124(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5804).
Ref 529445Bioorg Med Chem Lett. 2008 Jun 1;18(11):3338-43. Epub 2008 Apr 15.P2Y1 receptor antagonists as novel antithrombotic agents.

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