Drug Information

Drug General Information
Drug ID
D0G5CP
Former ID
DNC010811
Drug Name
4'-(6-Methoxypyridin-3-yl)biphenyl-3-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530868]
Formula
C18H15NO2
Canonical SMILES
COC1=NC=C(C=C1)C2=CC=C(C=C2)C3=CC(=CC=C3)O
InChI
1S/C18H15NO2/c1-21-18-10-9-16(12-19-18)14-7-5-13(6-8-14)15-3-2-4-17(20)11-15/h2-12,20H,1H3
InChIKey
JEDOKEGGMJNKGY-UHFFFAOYSA-N
PubChem Compound ID
46887511
Target and Pathway
Target(s) Estradiol 17 beta-dehydrogenase 1 Target Info Inhibitor [530868]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome The canonical retinoid cycle in rods (twilight vision)
WikiPathways Steroid Biosynthesis
Metabolism of steroid hormones and vitamin D
Prostate Cancer
References
Ref 530868Bioorg Med Chem. 2010 May 15;18(10):3494-505. Epub 2010 Mar 29.Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.
Ref 530868Bioorg Med Chem. 2010 May 15;18(10):3494-505. Epub 2010 Mar 29.Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.

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