TTD | Drug: D0G2GR

Drug General Information
Drug ID	D0G2GR
Former ID	DIB001638
Drug Name	OP-2507
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Discontinued in Phase 2	[545937]
Company	Ono Pharmaceutical Co Ltd
Formula	C25H41NO4
Canonical SMILES	[C@@H]12N=C(C[C@@H]1[C@@H](/C=C/[C@H]([C@H]1CC[C@H](CC1<br />)CCC)O)[C@@H](C2)O)CCCCC(=O)OC
CAS Number	CAS 101758-79-6
PubChem Compound ID	6917967
Target and Pathway
Target(s)	Prostacyclin receptor	Target Info	Modulator	[531344]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Platelet activation
Pathway Interaction Database	Thromboxane A2 receptor signaling
PathWhiz Pathway	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome	Prostanoid ligand receptors
Reactome	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	Endothelin Pathways
	Platelet homeostasis
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545937	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005417)
Ref 531344	Effect of a prostaglandin I(2) analog on the expression of thrombomodulin in liver and spleen endothelial cells after an extensive hepatectomy. Surg Today. 2011 Feb;41(2):230-6.

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Drug Information