Drug Information

Drug General Information
Drug ID
D0FS9K
Former ID
DIB003157
Drug Name
MINAMESTANE
Synonyms
FCE-24928; Minamestane < Rec INN >; 4-Aminoandrosta-1,4,6-triene-3,17-dione
Drug Type
Small molecular drug
Indication Bladder cancer [ICD9: 188; ICD10:C67] Terminated [545235]
Formula
C19H23NO2
Canonical SMILES
C[C@]12CC[C@H]3[C@@H](C=CC4=C(N)C(=O)C=C[C@]34C)[C@@H]1<br />CCC2=O
InChI
1S/C19H23NO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h3-4,8,10-13H,5-7,9,20H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
InChIKey
DAKHYLIFCYPHQW-KZQROQTASA-N
CAS Number
CAS 105051-87-4
PubChem Compound ID
65886
Target and Pathway
Target(s) Cytochrome P450 19 Target Info Inhibitor [533913], [551871]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis II
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome Endogenous sterols
WikiPathways Metapathway biotransformation
Tryptophan metabolism
Oxidation by Cytochrome P450
Ovarian Infertility Genes
Metabolism of steroid hormones and vitamin D
FSH signaling pathway
Integrated Breast Cancer Pathway
Phase 1 - Functionalization of compounds
References
Ref 545235Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002545)
Ref 533913High-performance liquid chromatographic determination of FCE 24928, a new aromatase inhibitor, in human plasma. J Chromatogr A. 1994 Feb 4;660(1-2):293-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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