Drug Information

Drug General Information
Drug ID
D0F4JK
Former ID
DIB011432
Drug Name
CE-224535
Synonyms
CP-23575
Drug Type
Small molecular drug
Indication Arthralgia [ICD10:M25.5] Phase 2/3 [522242]
Company
Pfizer Inc
Formula
C22H29ClN4O6
Canonical SMILES
C1CCCCC(C1)(O)CNC(=O)c1c(ccc(c1)n1ncc(=O)n(c1=O)C[C@H](<br />COC)O)Cl
PubChem Compound ID
11547499
Target and Pathway
Target(s) P2X purinoceptor 7 Target Info Antagonist [531823]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome The NLRP3 inflammasome
WikiPathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 522242ClinicalTrials.gov (NCT00628095) Study of CE-224,535 A Twice Daily Pill To Control Rheumatoid Arthritis In Patients Who Have Not Totally Improved With Methotrexate. U.S. National Institutes of Health.
Ref 531823Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate. J Rheumatol. 2012 Apr;39(4):720-7.

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