Drug Information

Drug General Information
Drug ID
D0F4IG
Former ID
DIB003717
Drug Name
DS-4574
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [544688]
Company
Daiichi Seiyaku Co Ltd
Formula
C13H16N6OS
Canonical SMILES
n12c(nc3c(c1=O)[nH]nn3)sc(n2)CCC1CCCCC1
CAS Number
CAS 118314-35-5
PubChem Compound ID
159491
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator [533854]
Leukotriene CysLT2 receptor Target Info Modulator [533854]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 544688Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000587)
Ref 533854Inhibitory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene receptor antagonism, on gastric acid secretion in rats. Eur J Pharmacol. 1994 Apr 1;255(1-3):229-34.

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